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Dde Biotin Picolyl Azide (CCT-1186)

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Description

Dde Biotin Picolyl Azide is an azide-activated cleavable biotin probe that allows for efficient recovery of avidin-bound protein complexes in affinity-based assays. This reagent contains a biotin moiety linked to azide group through a spacer arm containing a hydrazine-cleavable Dde moiety. Under mild conditions (2% aqueous hydrazine), the Dde liner is cleaved, releasing the biotin tag and any avidin conjugate bound to it.

Specifications

Unit Size1 mg, 5 mg, 25 mg
Molecular weight815.98
Molecular weight left behind220.24
Chemical compositionC38H57N9O9S
CAS2055048-42-3
SolubilityDMSO, DMF, THF, DCM, Chloroform
AppearanceOil to amorphous solid
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Howell, A. R., et al. (2021). α-Methylene-β-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum. Chembiochem.22 (3), 505-515. [PubMed]
  2. Matthew E. G., et al. (2017). Comprehensive Mapping of O-GlcNAc Modification Sites Using a Chemically Cleavable Tag. Mol. Biosyst, 12: 1756–59. [PubMed]
  3. Gertsik N., et al. (2017). Mapping the Binding Site of BMS-708163 on y-Secretase with Cleavable Photoprobes. Cell Chemical Biology, 32: 3-8. [PubMed]
  4. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem., 25: 698-706. [PubMed]
  5. Yang Y., et al. (2013). Cleavable Trifunctional Biotin Reagents for Protein Labeling, Capture, and Release. Chem. Commun., 48: 5366-86. [PubMed]
  6. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,51: 5852–56. [PubMed]
 

Applicable patents and legal notices are available at legal notices.

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