Germinal center (GC) reaction in the spleen after acute viral infection. After recognition of viral antigens, T cells (in blue) migrate from the T cell zone into the follicle where they interact with B cells (in purple). The T cells ‘help’ B cells, instructing the formation of GCs (in green) in which virus-specific B cells undergo selection, class switching and somatic hypermutation to secrete anti-viral antibodies to clear the infection.

Please find additional information about this work here:

http://www.cell.com/immunity/fulltext/S1074-7613(16)30142-X

Products used: B-1075-5,H-1000-10,H-3300-250