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Unconjugated Ricinus Communis Agglutinin II (RCA II, RCA60, ricin)

Catalog Number: L-1090

Availability: In stock

Unit Size: 10 mg
Overview

    TOXIC! This product is not available for purchase online. Please call Vector Laboratories for ordering information. 

    Ricinus communis agglutinin II is an extremely toxic glycoprotein consisting of two disulfide-linked chains of about 28 kDa and 32 kDa, termed A and B chain, respectively. The B chain can bind to cell surfaces via galactose or N-acetylgalactosamine residues of membrane glycoconjugates and facilitates the transport of the lectin into the cell. The A chain has an enzyme activity which can catalytically block protein synthesis and is so toxic that only a single molecule of A chain is required to kill a cell. Alone, the A chain is incapable of entering the cell and is thus not toxic.

    RCA II appears to be a family of related lectins with different toxicities. Our RCA II is the most toxic lectin of this family, probably ricin D, having an I.P. L.D50 in 20 g mice of less than 50 ng.

    Additional Information

    Catalog Number L-1090
    Unit Size 10 mg
    Country of Manufacture United States
    Applications Immunohistochemistry / Immunocytochemistry, Immunofluorescence, Blotting Applications, Glycobiology
    Conjugate Unconjugated
    Sugar Specificity Galactose, N-Acetylgalactosamine, Lactose
    Call For Price Yes
Additional Info

    Details

    TOXIC! This product is not available for purchase onine. Please call Vector Laboratories for ordering information.

    Ricinus communis agglutinin II is an extremely toxic glycoprotein consisting of two disulfide-linked chains of about 28 kDa and 32 kDa, termed A and B chain, respectively. The B chain can bind to cell surfaces via galactose or N-acetylgalactosamine residues of membrane glycoconjugates and facilitates the transport of the lectin into the cell. The A chain has an enzyme activity which can catalytically block protein synthesis and is so toxic that only a single molecule of A chain is required to kill a cell. Alone, the A chain is incapable of entering the cell and is thus not toxic.

    RCA II appears to be a family of related lectins with different toxicities. Our RCA II is the most toxic lectin of this family, probably ricin D, having an I.P. L.D50 in 20 g mice of less than 50 ng.

    Inhibiting/Eluting Sugar: 200 mM galactose or lactose

    Please note: Due to the toxicity of this product, special packaging is required and there is an additional shipping charge, sold in USA only.

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