Shopping Cart (0)
$0.00

You have no items in your shopping cart.

Unconjugated Peanut Agglutinin (PNA)

Catalog Number: L-1070

Availability: In stock

Product Name Unit Size Price Qty
Unconjugated Peanut Agglutinin (PNA) 5 mg
$80.00
Unconjugated Peanut Agglutinin (PNA) 10 mg
$130.00
Unconjugated Peanut Agglutinin (PNA) 25 mg
$250.00

Sheep trachea:  Peanut agglutinin (brown, Vector DAB). Zoom

Overview

    Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N-acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. With certain exceptions, the receptor sequence for PNA is normally sialylated which prevents the lectin from binding to its receptor oligosaccharide (see Jacalin). Even sialic acid which is not bound directly to the receptor sugars may inhibit binding. The presence of calcium ions in diluents can enhance the binding of PNA to receptors, possibly by neutralizing the negative charges on sialic acid residues adjacent to the receptor sequence.

    Additional Information

    Catalog Number L-1070
    Unit Size 5 mg, 10 mg, 25 mg
    Country of Manufacture United States
    Applications Immunohistochemistry / Immunocytochemistry, Immunofluorescence, Blotting Applications, Glycobiology
    Conjugate Unconjugated
    Sugar Specificity Galactose
Additional Info

    Details

    Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N-acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. With certain exceptions, the receptor sequence for PNA is normally sialylated which prevents the lectin from binding to its receptor oligosaccharide (see Jacalin). Even sialic acid which is not bound directly to the receptor sugars may inhibit binding. The presence of calcium ions in diluents can enhance the binding of PNA to receptors, possibly by neutralizing the negative charges on sialic acid residues adjacent to the receptor sequence.

    PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa. In addition, PNA binding can be used to measure cellular maturity in lymphoid tissues, to distinguish a variety of lymphocyte subpopulations in man and experimental animals, and to measure the levels of lymphoid cell populations in many diseases. PNA can be employed in the fractionation of stem cells in mice for use in bone marrow transplantation across histocompatibility barriers.

    A major cell surface receptor for PNA may be asialo GM1 ganglioside. Since PNA shares specificity with the antibody to this glycolipid, PNA and the antibody can be used interchangeably in some applications.

    Inhibiting/Eluting Sugar: 200 mM galactose
Reviews

    Write Your Own Review

    You're reviewing: Unconjugated Peanut Agglutinin (PNA)