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Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)

Catalog Number: L-1410

Availability: In stock

$100.00
Unit Size: 5 mg

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Overview

    Isolated from the cultivated banana Musa paradisiaca, banana lectin (BanLec) is a very stable mannose- and glucose-binding lectin consisting of two identical 15 kDa subunits and a reported isoelectric point of pH 7.3. Although structurally related to the Jacalin family of lectins, BanLec recognizes internal α(1,3) glucosyl- and mannosyl- residues and has also been reported to bind β(1,3) and β(1,6) glucosyl-structures.

    Like Galanthus nivalis lectin, BanLec has been shown to bind gp 120 glycoprotein, an important envelope component of the human immunodeficiency virus (HIV-1), and to strongly inhibit HIV-1 entry into cells. Glycoproteins on the surface of other viruses are also likely to be recognizable by BanLec. This lectin has been reported to be a potent mitogen for peripheral T-cells in the presence of interleukin-2, and appears likely to be a cause of allergic reaction to bananas, since IgG4 antibodies against BanLec have been detected in humans.

    Additional Information

    Catalog Number L-1410
    Unit Size 5 mg
    Country of Manufacture United States
    Applications Immunohistochemistry / Immunocytochemistry, Immunofluorescence, Blotting Applications, Glycobiology, Mitogenic Stimulation
    Conjugate Unconjugated
    Sugar Specificity Mannose, Glucose
Additional Info

    Details

    Isolated from the cultivated banana Musa paradisiaca, banana lectin (BanLec) is a very stable mannose- and glucose-binding lectin consisting of two identical 15 kDa subunits and a reported isoelectric point of pH 7.3. Although structurally related to the Jacalin family of lectins, BanLec recognizes internal α(1,3) glucosyl- and mannosyl- residues and has also been reported to bind β(1,3) and β(1,6) glucosyl-structures.

    Like Galanthus nivalis lectin, BanLec has been shown to bind gp 120 glycoprotein, an important envelope component of the human immunodeficiency virus (HIV-1), and to strongly inhibit HIV-1 entry into cells. Glycoproteins on the surface of other viruses are also likely to be recognizable by BanLec. This lectin has been reported to be a potent mitogen for peripheral T-cells in the presence of interleukin-2, and appears likely to be a cause of allergic reaction to bananas, since IgG4 antibodies against BanLec have been detected in humans.

    Inhibiting/eluting sugar: 200 mM α-methyl mannoside or mannose
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Protocols/Data Sheet/SDS

    Protocols/Data Sheet/SDS

    Data Sheet Lectin Brochure SDS