SHNH (HyNic for Technetium Labeling)


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SKU Unit Size Price
S-1001-010 10 mg

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SHNH (Succinimidyl 6-hydraziniumnicotinate hydrochloride) is used to incorporate HyNic (6-hydrazinonicotinamide) linkers on proteins, peptides and other amine-containing molecules for Technetium-99m (Tc-99m) labeling. SHNH is a bifunctional linker that incorporates HyNic through amino groups on biomolecules via an NHS ester. HyNic groups were initially developed to link Tc-99m to peptides and proteins for in vivo imaging. This procedure is still used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope.


More Information
Label/Modifier Type HyNic
Reactivity 4FB
Recommended Storage Desiccated: -15° to -25°C
Applications Antibody Labeling, Antisense/RNAi, Aptamers
Other Name(s) SoluLINK Bioconjugation


Technical Information


SHNH is an bifunctional aromatic hydrazine linker used to incorporate HyNic (6-hydrazinonicotinamide) linkers onto biomolecules through their amino group via an activated ester (i.e. NHS; Figure 1). HyNic groups were developed to link Tc-99m to proteins for in vivo imaging.


Figure 1: Scheme presenting the modification of a protein with SHNH.


The number of HyNic linkers incorporated on biomolecules can be quantified colorimetrically on reaction with 2-sulfobenzaldehyde (catalog number S-2005-100). The product yields a chromophore that absorbs at A350 with a molar extinction coefficient of 28,500 L/(mol*cm).

Intellectual Property

SoluLINK® Bioconjugation For Research Use Only. Not for use in diagnostic procedures. For additional licensing restrictions, please see the license agreement at

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.

TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.

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