SHNH (HyNic for Technetium Labeling)

S-1001-010

This product has been discontinued.

Please contact Technical Support @ technical@vectorlabs.com for assistance in finding an alternative.
SKU Unit Size Price
S-1001-010 10 mg
$350.00

To request a quote for products:

  1. Click “Contact Us” in the header bar above;
  2. Click “Customer Service”;
  3. Complete the form and provide the following information in the “Comments” section: note you would like a quote, item number (SKU) and quantity;
  4. Click “Submit”.

Description

SHNH (Succinimidyl 6-hydraziniumnicotinate hydrochloride) is used to incorporate HyNic (6-hydrazinonicotinamide) linkers on proteins, peptides and other amine-containing molecules for Technetium-99m (Tc-99m) labeling. SHNH is a bifunctional linker that incorporates HyNic through amino groups on biomolecules via an NHS ester. HyNic groups were initially developed to link Tc-99m to peptides and proteins for in vivo imaging. This procedure is still used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope.

Specifications

More Information
Label/Modifier Type HyNic
Reactivity 4FB
Recommended Storage Desiccated: -15° to -25°C
Applications Antibody Labeling, Antisense/RNAi, Aptamers
Other Name(s) SoluLINK Bioconjugation

Documents

Technical Information

Introduction:

SHNH is an bifunctional aromatic hydrazine linker used to incorporate HyNic (6-hydrazinonicotinamide) linkers onto biomolecules through their amino group via an activated ester (i.e. NHS; Figure 1). HyNic groups were developed to link Tc-99m to proteins for in vivo imaging.

 

Figure 1: Scheme presenting the modification of a protein with SHNH.

 


The number of HyNic linkers incorporated on biomolecules can be quantified colorimetrically on reaction with 2-sulfobenzaldehyde (catalog number S-2005-100). The product yields a chromophore that absorbs at A350 with a molar extinction coefficient of 28,500 L/(mol*cm).

Home Bioconjugation Reagents Conjugation Linkers SHNH (HyNic for Technetium Labeling)