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t-boc-N-amido-dPEG®₃-amine (QBD-10225)

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Description

t-boc-N-amido-dPEG®3-amine, product number QBD-10225, is a monoprotected, diamine-functionalized, homobifunctional crosslinking PEGylation reagent containing a short, single molecular weight PEG linker. One of the two primary carboxylate-reactive groups is protected as a tert-butyl carbamate. Both ends of the molecule react with carboxylic acids, aldehydes, and ketones. Carboxylic acids react with this product to form amide bonds, while reactions with aldehydes and ketones form Schiff bases that are reducible to secondary amines. The mono-protected end of the molecule gives the user tighter control over crosslinking.

Specifications

Unit Size1000 mg
Molecular Weight320.42; single compound
Chemical formulaC₁₅H₃₂N₂O₅
CAS194920-62-2
Purity> 98%
SpacersdPEG® Spacer is 15 atoms and 16.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting system with Streptavidin Mutants, D. Scott Wibur, Steven I. Park, Ming-Kuan Chyan, Feng Wan, Donald K. Hamlin, Jaideep Shenoi, Yukang Lin, Shani M. Wilbur, Franz Buchegger, Anastasia Pantelias, John M. Pagel, and Oliver W. Press. Bioconjugate Chem. 2010, 21 (7), pp 1225–1238. July 2, 2010. DOI: 10.1021/bc100030q.

Novel Nanoassemblies Composed of Squfalenoyl—Paclitaxel Derivatives: Synthesis, Characterization, and Biological Evaluation, Franco Dosio, L. Harivardhan Reddy, Annalisa Ferrero, Barbara Stella, Luigi Cattel, and Patrick Couvreur. Bioconjugate Chem. 2010, 21 (7), pp 1349–1361. July 2, 2010. DOI: 10.1021/bc100154g.

A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis. Daniel J. Wilson, Ce Shi, Benjamin P. Duckworth, Joseph M. Muretta, Ujjini Manjunatha, Yuk Y. Sham, David D. Thomas, and Courtney C. Aldrich. Analytical Biochemistry. 2011, 416 (1) pp 27-38. September 2011. DOI:10.1016/j.ab.2011.05.003.

Thiol-Mediated Anchoring of Ligands to Self-Assembled Monolayers for Studies of Biospecific Interactions. Kunal V. Gujraty, Randolph Ashton, Sridhar R. Bethi, Sandesh Kate, Christopher J. Faulkner, G. Kane Jennings, and Ravi S. Kane. Langmuir. 2006, 22 (24) pp 10157–10162. October 19, 2006.DOI: 10.1021/la0621463.

Design, Synthesis, and Validation of a Branched Flexible Linker for Bioactive Peptides. Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J. Hruby, Robert J. Gillies, and Eugene A. Mash. J. Org. Chem. 2007, 72 (5) pp 1675–1680. February 6, 2007. DOI: 10.1021/jo062276g.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4. Orzala Sharif, Huiyong Hu, Heath Klock, Eric N. Hampton, Edward Nigoghossian, Mark W. Knuth, Jason Matzen, Paul Anderson, Richard Trager, Tetsuo Uno, Richard J. Glynne, Sassan M. Azarian, Jeremy S. Caldwell , Achim Brinker. Analytical Biochemistry. 2009, 392, (2) PP 162–168. September 15 , 2009. doi.org/10.1016/j.ab.2009.05.038.

Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand. Wenhao Liu, Andrew B. Greytak, Jungmin Lee, Cliff R. Wong, Jongnam Park, Lisa F. Marshall, Wen Jiang, Peter N. Curtin, Alice Y. Ting, Daniel G. Nocera, Dai Fukumura, Rakesh K. Jain and Moungi G. Bawendi. J. Am. Chem. Soc. 2010, 132 (2) pp 472–483. December 21, 2009. DOI: 10.1021/ja908137d.

Applicable patents and legal notices are available at legal notices.

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