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Neuronal Glycobiology Reagents

Detection of neurons and support structures using lectins has provided valuable information in the field of neuroscience. For example, small sensory neurons can be broadly classified into two groups based on expression levels of neuropeptides and nerve growth factor receptor. One group expresses a cell surface glycoprotein that binds the lectin Griffonia simplicifolia I, Isolectin B4. As a result, it has become useful to classify neurons as IB4 positive or IB4 negative. Other lectins, such as Lycopersicon esculentum, Ricinus communis agglutinin I, peanut agglutinin, and wheat germ agglutinin have been used to detect various types of glia. Lectins commonly used in neurobiology are listed in this section.

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