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Methyltetrazine-PEG4-NHS Ester (CCT-1069)

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Description

Methyltetrazine-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary TCO-containing molecules. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Specifications

Unit Size4×2 mg, 10mg, 25 mg, 100 mg, 500 mg, 1000 mg
Molecular weight533.53
Chemical compositionC24H31N5O9
CAS1802907-92-1
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceRed crystalline
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Marquard, A.N., et al. (2020). Expanding the Scope of Antibody Rebridging with New Pyridazinedione-TCO Constructs. Bioconjug Chem.31(6), 1616-23. [PubMed]

Applicable patents and legal notices are available at legal notices.

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