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Ricinus communis agglutinin II (RCA II, RCA60)

Ricinus communis agglutinin II is an extremely toxic glycoprotein consisting of two disulfide-linked chains of about 28 kDa and 32 kDa, termed A and B chain, respectively. The B chain can bind to cell surfaces via galactose or N-acetylgalactosamine residues of membrane glycoconjugates and facilitates the transport of the lectin into the cell. The A chain has an enzyme activity which can catalytically block protein synthesis and is so toxic that only a single molecule of A chain is required to kill a cell. Alone, the A chain is incapable of entering the cell and is thus not toxic.

RCA II appears to be a family of related lectins with different toxicities. Our RCA II is the most toxic lectin of this family, probably ricin D, having an I.P. L.D50 in 20 g mice of less than 50 ng.

Please note: Due to the toxicity of this product, special packaging is required and there is an additional shipping charge, sold in USA only.
 

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