Products Results    (7)

Peanut agglutinin (PNA)

Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N-acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. With certain exceptions, the receptor sequence for PNA is normally sialylated which prevents the lectin from binding to its receptor oligosaccharide (see Jacalin). Even sialic acid which is not bound directly to the receptor sugars may inhibit binding. The presence of calcium ions in diluents can enhance the binding of PNA to receptors, possibly by neutralizing the negative charges on sialic acid residues adjacent to the receptor sequence. 

PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa. In addition, PNA binding can be used to measure cellular maturity in lymphoid tissues, to distinguish a variety of lymphocyte subpopulations in man and experimental animals, and to measure the levels of lymphoid cell populations in many diseases. PNA can be employed in the fractionation of stem cells in mice for use in bone marrow transplantation across histocompatibility barriers.

A major cell surface receptor for PNA may be asialo GM1 ganglioside. Since PNA shares specificity with the antibody to this glycolipid, PNA and the antibody can be used interchangeably in some applications. 

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  1. Cy5 labeled Peanut Agglutinin (PNA)
    Cy5 labeled Peanut Agglutinin (PNA)
    Cat. No: CL-1075
    Unit Size: 1 mg
  2. Cy3 labeled Peanut Agglutinin (PNA)
    Cy3 labeled Peanut Agglutinin (PNA)
    Cat. No: CL-1073
    Unit Size: 1 mg
  3. Sheep trachea:  Peanut agglutinin (brown, Vector DAB).
    Unconjugated Peanut Agglutinin (PNA)
    Cat. No: L-1070
    Unit Size: 5 mg, 25 mg
  4. Fluorescein labeled Peanut Agglutinin (PNA)
    Fluorescein labeled Peanut Agglutinin (PNA)
    Cat. No: FL-1071
    Unit Size: 5 mg, 10 mg
  5. Agarose Bound Peanut Agglutinin (PNA)
    Agarose Bound Peanut Agglutinin (PNA)
    Cat. No: AL-1073
    Unit Size: 2 ml, 5 ml
  6. Rhodamine labeled Peanut Agglutinin (PNA)
    Rhodamine labeled Peanut Agglutinin (PNA)
    Cat. No: RL-1072
    Unit Size: 5 mg
  7. Sheep trachea:  Peanut agglutinin (brown, Vector DAB).
    Biotinylated Peanut Agglutinin (PNA)
    Cat. No: B-1075
    Unit Size: 5 mg
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