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Cy7 DBCO (CCT-1047)

Description

Cy7 DBCO is a bright and photostable near-IR probe that spectrally similar to Alexa Fluor® 750, DyLight® 750, and IRDye® 750 dye. The Cy7 DBCO is water-soluble, hydrophilic dye often a reagent of choice for assay where minimal non-specific binding and exceptional brightness is required. The fluorescence of Cy7 DBCO is pH insensitive from pH 4 to pH 10 and produces minimal autofluorescence of biological specimens in this region of the spectrum. Fluorescence of this long-wavelength Cyanine dye is not visible to the human eye but is readily detected by most imaging systems.

Cy7 DBCO reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. In application where the presence of copper is a concern Cy7 DBCO is an ideal alternative to copper requiring fluorescent alkynes.

Cy7 DBCO reagent is not suitable for staining intracellular components of fixed and permeabilized cells due to high backgrounds.

Specifications

Unit Size1 mg, 5 mg, 25 mg, 100 mg
Abs/Em Maxima753/775 nm
Extinction Coefficient
255,000
Spectrally Similar DyesAlexa Fluor® 750, RDye® 750, CF® 750 Dye, DyLight® 750
Molecular weight1259.53 (protonated)
CASN/A
SolubilityWater, DMSO, DMF
Purity>95% (HPLC)
AppearanceDark green solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Abs/Em Spectra

Cy Cy Vectorlabs

Selected References

  1. Willems, L. I., et al. (2020). Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins. J Am Chem Soc.142 (37), 15729-15739. [PubMed]
  2. Van Der Wal, S., et al. (2018). Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches. Chembiochem.19(16), 1758-65. [PubMed]

Applicable patents and legal notices are available at legal notices.

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