Bis-Maleimide amine,TFA salt (QBD-10232)

Description

Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate groups modify the α and ε amine of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.
Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.

Specifications

Documents

References

1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
2. Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung Kim, Hai Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee. Bioconjugate Chem. 2011, 22 (4), pp 625–632. March 14, 2011. DOI: 10.1021/bc100404x.
3. Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators. Justin M. Scheer, Wendy Sandoval, J. Michael Elliott, Lily Shao, Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen. PLOS ONE. 2012, 7 (12) e51817. December 20, 2012. DOI: 10.1371/journal.pone.0051817.