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Biotin-dPEG®₁₂-DBCO (QBD-11811)



Biotin-dPEG®12-DBCO, product number QBD-11811, is a click chemistry biotinylation reagent built on a medium-length (40 atoms, 46.3 Å) single molecular weight PEG linker with a discrete chain length (dPEG®) and functionalized with dibenzylcyclooctyne (DBCO) for strain-promoted azide-alkyne cycloaddition (SPAAC), also known as “copper-free click chemistry.” The DBCO functional group reacts with any available azide moiety on a target molecule via SPAAC. The amphiphilic dPEG® spacer imparts water solubility to the biotin label, reducing non-specific hydrophobic interactions and reducing or eliminating concerns over aggregation and precipitation due to biotin’s well-known hydrophobicity. Because the hydrophilic dPEG® linker is longer than the classic, hydrophobic LC-LC-biotin, the biotin moiety has potentially better access to the binding pockets of avidin and streptavidin. Peptide and protein modification can be used to introduce suitable azide partners for this biotin labeling compound.


Unit Size10 mg, 25 mg, 1000 mg
Molecular Weight1102.34; single compound
Chemical formulaC₅₅H₈₃N₅O₁₆S
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.3 Å
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, DMF, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Engineering the Orientation, Density, and Flexibility of Single-Domain Antibodies on Nanoparticles To Improve Cell Targeting. Ken W. Yong, Daniel Yuen, Moore Z. Chen, Angus P. R. Johnston. ACS Appl. Mater. Interfaces 2020, 12, 5, 5593-5600. January 9, 2020. DOI: 10.1021/acsami.9b20993

Applicable patents and legal notices are available at legal notices.

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