NEUROBIOTIN™-Plus Tracer is impervious to cleavage and breakdown by biotinidase.
|Unit Size||5 mg|
|Country of Manufacture||United States|
|Neuronal Tracer - Direction of Transport||Anterograde/Retrograde|
|Detection Method||Avidin(Streptavidin)/Biotin Method, Chromogenic, Fluorescence|
Investigators have identified rapid degradation of injected tracers such as biocytin due to the presence of biotinidase activity in brain tissue*. This loss of stability of the tracer significantly reduces the viable postinjection period and may compromise complete detection of a neural network. NEUROBIOTIN™ -Plus was designed to be impervious to cleavage and breakdown by biotinidase. This newly synthesized biotin-containing compound contains fixable amine groups, is highly soluble and has a low molecular weight. These characteristics make it an ideal candidate for experiments requiring long postinjection survival times and optimal uptake along the entire neural tract.
NEUROBIOTIN™ -Plus shares the same key advantages of NEUROBIOTIN™ Tracer over biocytin and other neuronal labels:
NEUROBIOTIN™ -Plus can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods.
*Mishra, A. et al (2010) ACS Chem. Neurosci. 1:129-138.
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