Lectins from Vector Labs Now Screened by the National Center for Functional Glycomics (NCFG)

Lung tissue from a resting adult mouse stained with Fluorescein-labeled Aleuria aurantia lectin (AAL; green), and biotinylated Concanavalin A (Con A) followed by DyLight® 549 Streptavidin (red). Image courtesy of Dr. Brian A Cobb, Case Western University, School of Medicine.

Elucidating carbohydrate structures present in nature can be as challenging as it is fascinating. Greater understanding of lectin binding specificities can help determine details of glycan structure and help address related questions of function.

The National Center for Functional Glycomics (NCFG), with the support of the NIH Common Fund for Glycosciences, will be screening a selection of Vector Labs's lectins. Using the Consortium for Functional Glycomics (CFG) glycan arrays, the NCFG analyzes the glycan specificity of each of our lectin lots, and provides these detailed lectin-glycan binding data on the NCFG website. The goal of this NCFG project is to support rigorous and reproducible glycobiology experiments.

These data provide uniquely valuable insights into glycan structures on the glycoproteins you are studying:

  • Binding specificity of each lectin, for hundreds of gycan structures in the array
  • Data tabulated and conveniently summarized as a binding array, with peak height indicating degree of binding for each glycan
  • Specific and detailed data on carbohydrate structure
  • Lot-specific data—for confidence in the reproducibility of your binding data
ConA-Fluorescein Graph

Binding data for Fluorescein labeled Concanavalin A (ConA; Vector Labs Cat. No. FL-1001). Note the binding specificity for each of the 600 glycans in the array is shown as a peak.

Visit the NCFG site for more information on this validation data, and visit the Vector Labs website to browse all our lectin and glycobiology products.