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Fluorescein Labeled Musa Paradisiaca (Banana) Lectin (BanLec)

Catalog Number: FL-1411

Availability: In stock

$95.00
Unit Size: 2 mg

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Overview

    Isolated from the cultivated banana Musa paradisiaca, banana lectin (BanLec) is a very stable mannose- and glucose-binding lectin consisting of two identical 15 kDa subunits and a reported isoelectric point of pH 7.3. Although structurally related to the Jacalin family of lectins, BanLec recognizes internal α(1,3) glucosyl- and mannosyl- residues and has also been reported to bind β(1,3) and β(1,6) glucosyl-structures.

    Like Galanthus nivalis lectin, BanLec has been shown to bind gp 120 glycoprotein, an important envelope component of the human immunodeficiency virus (HIV-1), and to strongly inhibit HIV-1 entry into cells. Glycoproteins on the surface of other viruses are also likely to be recognizable by BanLec. This lectin has been reported to be a potent mitogen for peripheral T-cells in the presence of interleukin-2, and appears likely to be a cause of allergic reaction to bananas, since IgG4 antibodies against BanLec have been detected in humans.

    Fluorescein labeled BanLec has an appropriate number of fluorochromes bound to provide the optimum staining characteristics for this lectin. This conjugate is supplied essentially free of unconjugated fluorochromes. The excitation maximum is at 495 nm and the emission maximum is at 515 nm.

    Additional Information

    Catalog Number FL-1411
    Unit Size 2 mg
    Country of Manufacture United States
    Applications Immunofluorescence, Glycobiology
    Conjugate Fluorescein
    Color of Fluorescence Green
    Sugar Specificity Mannose, Glucose
Additional Info

    Details

    Isolated from the cultivated banana Musa paradisiaca, banana lectin (BanLec) is a very stable mannose- and glucose-binding lectin consisting of two identical 15 kDa subunits and a reported isoelectric point of pH 7.3. Although structurally related to the Jacalin family of lectins, BanLec recognizes internal α(1,3) glucosyl- and mannosyl- residues and has also been reported to bind β(1,3) and β(1,6) glucosyl-structures.

    Like Galanthus nivalis lectin, BanLec has been shown to bind gp 120 glycoprotein, an important envelope component of the human immunodeficiency virus (HIV-1), and to strongly inhibit HIV-1 entry into cells. Glycoproteins on the surface of other viruses are also likely to be recognizable by BanLec. This lectin has been reported to be a potent mitogen for peripheral T-cells in the presence of interleukin-2, and appears likely to be a cause of allergic reaction to bananas, since IgG4 antibodies against BanLec have been detected in humans.

    Fluorescein labeled BanLec has an appropriate number of fluorochromes bound to provide the optimum staining characteristics for this lectin. This conjugate is supplied essentially free of unconjugated fluorochromes. The excitation maximum is at 495 nm and the emission maximum is at 515 nm.

    Accompanying each fluorescent lectin is an analysis data sheet summarizing the results of our quality control tests and providing pertinent information on the product. All of these reagents are supplied as solutions perserved with sodium azide.

    Inhibiting/eluting sugar: 200 mM α-methyl mannoside or mannose
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Protocols/Data Sheet/SDS

    Protocols/Data Sheet/SDS

    Data Sheet Lectin Brochure SDS