Posts tagged 'Glycobiology'

Leveraging Lectins for Glycan Analysis

Incorporating glycan analysis into your workflows is easier than you may think–especially when you use lectins, which are compatible with many commonly used lab assays. Join us as we walk through the key considerations to help you get started.
January 5, 2022

Our Top 10 Posts of 2021 Will Lend You a Helping Hand in the Lab

How can we do even more to help researchers?  That’s a question we ask a lot here at Vector Laboratories, and this June it led us to launch a blog. Since then, it’s been our honor to bring you stories about innovative scientists and share insights to help you advance your research. Here are a few of our most popular posts from 2021, and we’re looking forward to many more tips and stories in 2022!

December 15, 2021

Lectins 101: How Plant Lectins Can Accelerate Cancer Biomarker Discovery

Lectins are essential in recognizing abnormal cell glycome and mediating tumor progression. That said, they can also be leveraged to enhance our knowledge of the glycome profiles of various cancers.
November 10, 2021

What’s in a name? Glycans and sugars and lectins … Oh my!

Why does glycobiology—the study of sugar chains—matter so much to our health? From the simplest to the most branched, carbohydrates are the key players in cellular functions—both healthy and pathological. This article summarizes the key elements of glycobiology in a nutshell.
November 3, 2021

The Inhibitory Effect of Bisecting N-Acetylglucosamine on Breast Cancer

Glycosylation networks have massive biomarker potential for breast cancer diagnosis and treatment. This study explores yet another alteration in breast cancer glycan profile: bisecting GlcNAc.
October 6, 2021

HOMER3: A Novel Biomarker in Muscle-Invasive Bladder Cancer

The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
September 22, 2021

Red Blood Cell Mannoses: Role in Sickle Cell Diseases and Malaria Resistance

This study explores how the sickle cell trait could help millions of people in Sub-Saharan Africa, a high-risk malaria zone, develop resistance against malaria.
August 25, 2021

The Sialylation Pathways in Pancreatic Cancer and Their Role in Tumor Microenvironment Differentiation

Hypersialylation of glycans is one of the key drivers in cell differentiation in cancer, including pancreatic ductal adenocarcinoma (PDAC) cells. In this article, we review a study investigating how this mechanism led to the differentiation of tumor monocytes into malignant tumor macrophages associated with low survival rates in patients.
July 21, 2021

Macrophage-derived Microparticles to Improve the Efficacy of Anti-PD-1 Antibodies in Tumors

In this publication highlight, we review a study examining the impact of macrophage-derived microparticles on the tumor microenvironment and their synergistic effect on anti-PD-1 antibody activity.
June 30, 2021