Publication Highlight

Breast Cancer Awareness Month: Impact of polysialylation in breast cancer outcomes

In this post we highlight a recent work from the University of British Columbia on the role of polySia, CD56, and polysialyltransferases in the breast tumor microenvironment.

September 28, 2022

Leukemia and Lymphoma Awareness Month: Understanding blood cancers

To highlight the fight against these malignant blood cancer types, we will walk you through recent research publications that shed light on the complex mechanisms behind lymphoma and leukemia.

September 7, 2022

Hope for Spinal Muscular Atrophy through different research approaches

Spinal muscular atrophy is a serious genetic condition that results in the degeneration of motor neurons. Learn about research being performed to contribute to better outcomes.

August 24, 2022

Alzheimer's Awareness Month: The Impact of IL-17 Accumulation on Cognitive Deficit

Learn about the impact of IL-17 accumulation on cognitive impairment in this blog post for Alzheimer's Awareness Month.

June 1, 2022

Sea Lamprey in Glycobiology: Anti-Glycan Reagents from the depths of the Atlantic Ocean

The parasitic sea lamprey has long remained the fishermen’s nightmare for harming fish in the Atlantic Ocean. However, their unique immune system could pave the way to substantial improvements in human glycome analysis. We review a study that demonstrates how lampreys generate antibodies that are specific for diverse glycans. 

 

March 8, 2022

Bioconjugation reveals new therapeutic possibilities for autoimmune disorders

The use of several promising drugs as treatments for autoimmune and inflammatory diseases has long been limited due to their toxic side effects. Wang et al. demonstrate how these barriers could be overcome with a novel antibody-drug conjugate.
February 9, 2022

Improved Detection Strategies for Pancreatic Cancer: The Role of Imaging Mass Spectrometry and Lectin Analysis

Pancreatic cancer is one of the deadliest cancers, especially when diagnosed at a later stage because of the lack of accurate biomarkers. Linking these biomarkers to cellular modifications is a promising approach to improve tumor evaluation. In this blog article, we review a study that explores the role of N-glycan modifications in pancreatic tumors.
February 2, 2022

The Inhibitory Effect of Bisecting N-Acetylglucosamine on Breast Cancer

Glycosylation networks have massive biomarker potential for breast cancer diagnosis and treatment. This study explores yet another alteration in breast cancer glycan profile: bisecting GlcNAc.
October 6, 2021

HOMER3: A Novel Biomarker in Muscle-Invasive Bladder Cancer

The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
September 22, 2021