Publication Highlight

Alzheimer's Awareness Month: The Impact of IL-17 Accumulation on Cognitive Deficit

Learn about the impact of IL-17 accumulation on cognitive impairment in this publication highlight blog post for Alzheimer's Awareness Month.

June 1, 2022

Sea Lamprey in Glycobiology: Anti-Glycan Reagents from the depths of the Atlantic Ocean

The parasitic sea lamprey has long remained the fishermen’s nightmare for harming fish in the Atlantic Ocean. However, their unique immune system could pave the way to substantial improvements in human glycome analysis. We review a study that demonstrates how lampreys generate antibodies that are specific for diverse glycans. 

 

March 8, 2022

Bioconjugation reveals new therapeutic possibilities for autoimmune disorders

The use of several promising drugs as treatments for autoimmune and inflammatory diseases has long been limited due to their toxic side effects. Wang et al. demonstrate how these barriers could be overcome with a novel antibody-drug conjugate.
February 9, 2022

Improved Detection Strategies for Pancreatic Cancer: The Role of Imaging Mass Spectrometry and Lectin Analysis

Pancreatic cancer is one of the deadliest cancers, especially when diagnosed at a later stage because of the lack of accurate biomarkers. Linking these biomarkers to cellular modifications is a promising approach to improve tumor evaluation. In this blog article, we review a study that explores the role of N-glycan modifications in pancreatic tumors.
February 2, 2022

The Inhibitory Effect of Bisecting N-Acetylglucosamine on Breast Cancer

Glycosylation networks have massive biomarker potential for breast cancer diagnosis and treatment. This study explores yet another alteration in breast cancer glycan profile: bisecting GlcNAc.
October 6, 2021

HOMER3: A Novel Biomarker in Muscle-Invasive Bladder Cancer

The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
September 22, 2021

Microglial Activation and Soluble TREM2 as a Potential Biomarker of Alzheimer’s Disease

Since it was first described in 1906 by Alois Alzheimer, physicians and scientists have been searching for clues to the debilitating neurological condition Alzheimer’s disease (AD). To diagnose and treat the disease at its earliest stages, researchers are searching for additional biomarkers that can help guide our understanding of the disease.
September 15, 2021

Red Blood Cell Mannoses: Role in Sickle Cell Diseases and Malaria Resistance

This study explores how the sickle cell trait could help millions of people in Sub-Saharan Africa, a high-risk malaria zone, develop resistance against malaria.
August 25, 2021

The Sialylation Pathways in Pancreatic Cancer and Their Role in Tumor Microenvironment Differentiation

Hypersialylation of glycans is one of the key drivers in cell differentiation in cancer, including pancreatic ductal adenocarcinoma (PDAC) cells. In this article, we review a study investigating how this mechanism led to the differentiation of tumor monocytes into malignant tumor macrophages associated with low survival rates in patients.
July 21, 2021

Investigating Cross-Reactive Antibodies of SARS-CoV-2 with LIBRA-seq

In this publication highlight, we review the use of LIBRA-seq to characterize monoclonal antibodies from a recovered SARS-CoV donor, expanding our understanding of cross-reactive antibodies for coronavirus.
July 14, 2021