Publication Highlight

The Inhibitory Effect of Bisecting N-Acetylglucosamine on Breast Cancer

Glycosylation networks have massive biomarker potential for breast cancer diagnosis and treatment. This study explores yet another alteration in breast cancer glycan profile: bisecting GlcNAc.
October 6, 2021

HOMER3: A Novel Biomarker in Muscle-Invasive Bladder Cancer

The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
September 22, 2021

Microglial Activation and Soluble TREM2 as a Potential Biomarker of Alzheimer’s Disease

Since it was first described in 1906 by Alois Alzheimer, physicians and scientists have been searching for clues to the debilitating neurological condition Alzheimer’s disease (AD). To diagnose and treat the disease at its earliest stages, researchers are searching for additional biomarkers that can help guide our understanding of the disease.
September 15, 2021

Red Blood Cell Mannoses: Role in Sickle Cell Diseases and Malaria Resistance

This study explores how the sickle cell trait could help millions of people in Sub-Saharan Africa, a high-risk malaria zone, develop resistance against malaria.
August 25, 2021

The Sialylation Pathways in Pancreatic Cancer and Their Role in Tumor Microenvironment Differentiation

Hypersialylation of glycans is one of the key drivers in cell differentiation in cancer, including pancreatic ductal adenocarcinoma (PDAC) cells. In this article, we review a study investigating how this mechanism led to the differentiation of tumor monocytes into malignant tumor macrophages associated with low survival rates in patients.
July 21, 2021

Investigating Cross-Reactive Antibodies of SARS-CoV-2 with LIBRA-seq

In this publication highlight, we review the use of LIBRA-seq to characterize monoclonal antibodies from a recovered SARS-CoV donor, expanding our understanding of cross-reactive antibodies for coronavirus.
July 14, 2021

Macrophage-derived Microparticles to Improve the Efficacy of Anti-PD-1 Antibodies in Tumors

In this publication highlight, we review a study examining the impact of macrophage-derived microparticles on the tumor microenvironment and their synergistic effect on anti-PD-1 antibody activity.
June 30, 2021