Lectins are essential in recognizing abnormal cell glycome and mediating tumor progression. That said, they can also be leveraged to enhance our knowledge of the glycome profiles of various cancers.
Why does glycobiology—the study of sugar chains—matter so much to our health? From the simplest to the most branched, carbohydrates are the key players in cellular functions—both healthy and pathological. This article summarizes the key elements of glycobiology in a nutshell.
Autofluorescence can make it difficult or impossible to distinguish antigen-specific signal from non-specific background. Learn how you can reduce autofluorescence in your immunofluorescence workflow.
Immunohistochemistry (IHC) is an invaluable technique in a variety of fields—from basic research to clinical diagnosis—but using IHC to screen humanized antibodies in human tissue can be challenging. Learn how scientists are addressing those challenges, and how Vector Laboratories can help.
Protein in formalin-fixed tissue can undergo epitope masking, leading to reduction or elimination of antibody binding. Learn how antigen retrieval can reverse this masking.
No matter how you slice it, if your research includes immunohistochemistry or immunofluorescence, it’s a key part of your experimental workflow. If you aren’t the type of researcher who draws a heart around “Sectioning Day” on your lab calendar, cut yourself a little slack and read on for some tips and tricks.
Looking for insights into how to choose the right mounting medium for your applications? From understanding the importance of refractive index to technique tips, we’ve got you covered.
Picture this: a chemist walks into a lab and asks his colleagues how to transition some immunohistochemistry (IHC)-stained slides in a buffer solution to coverslip with a non-aqueous mounting media. From his perspective, it’s a simple problem, and it should have a similarly simple solution. Does it? Read this blog article to find out.
With applications ranging from drug targeting to genome sequencing, bioconjugation provides tools for more effective imaging and drug discovery methods. Join us as we explore the possibilities in this article.
When scientists detect targets of interest with immunohistochemistry (IHC), antibody binding and substrate detection alone often produce a perplexing picture where the target lacks context. Luckily there’s a solution. Counterstaining IHC samples after enzymatic detection spatially orients the target within its surroundings, which can help guide researchers as they analyze their results.
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