SpeakEasy Science Blog

HOMER3: A Novel Biomarker in Muscle-Invasive Bladder Cancer

The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
September 22, 2021

Microglial Activation and Soluble TREM2 as a Potential Biomarker of Alzheimer’s Disease

Since it was first described in 1906 by Alois Alzheimer, physicians and scientists have been searching for clues to the debilitating neurological condition Alzheimer’s disease (AD). To diagnose and treat the disease at its earliest stages, researchers are searching for additional biomarkers that can help guide our understanding of the disease.
September 15, 2021

Spontaneous reactions of the hydrazone

When it comes to linking two biomolecules together, the SoluLINK® technology offers a user-friendly solution with reliable and reproducible bioconjugation, which is a great option for what may initially seem to be a daunting task. Jim Williams serves as the Associate Director of Bioconjugation Technology, where he oversees bioconjugation product manufacturing and is highly involved in the design and manufacturing of custom and OEM conjugates.
September 8, 2021

Let’s Cut to the Chase: Tips and Tricks to Get the Most Out of Your Sectioning

No matter how you slice it, if your research includes immunohistochemistry or immunofluorescence, it’s a key part of your experimental workflow. If you aren’t the type of researcher who draws a heart around “Sectioning Day” on your lab calendar, cut yourself a little slack and read on for some tips and tricks.
September 1, 2021

Red Blood Cell Mannoses: Role in Sickle Cell Diseases and Malaria Resistance

This study explores how the sickle cell trait could help millions of people in Sub-Saharan Africa, a high-risk malaria zone, develop resistance against malaria.
August 25, 2021

The End of the Line: Considerations for Mounting Media Selection

Looking for insights into how to choose the right mounting medium for your applications? From understanding the importance of refractive index to technique tips, we’ve got you covered.
August 18, 2021

When No One Opens the Door and the Pathway Is Convoluted, Creativity Rules

Jose Ortiz is well on his way to completing a PhD, but his was not an easy journey. This and many other factors have influenced his academic journey as a non-traditional student and person of color.
August 18, 2021

The Waiting Game: A Search for a Streamlined IHC Protocol

Picture this: a chemist walks into a lab and asks his colleagues how to transition some immunohistochemistry (IHC)-stained slides in a buffer solution to coverslip with a non-aqueous mounting media. From his perspective, it’s a simple problem, and it should have a similarly simple solution. Does it? Read this blog article to find out.
August 11, 2021

There’s a New Mountant in Town

Earlier this year, Brittany Cederstrom, a research scientist at the Proteogenomic Research Institute for Systems Medicine (PRISM) in San Diego, California sampled VectaMount® Express Mounting Medium in her slide preparation workflow and compared it to her standard process with a competitor mounting medium.
July 30, 2021

Bioconjugation and Its Use in Biomolecular Research

With applications ranging from drug targeting to genome sequencing, bioconjugation provides tools for more effective imaging and drug discovery methods. Join us as we explore the possibilities in this article.
July 28, 2021