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Featuring:
Plus
quality reagents for:
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p53 Protein Antibody (clone BP53-12)
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Mouse monoclonal antibody suitable for immunohistochemistry and western blotting.
Functional Aspects:
p53 protein is crucial to normal regulation of cell growth and
is a suppressor of tumor cell proliferation. A high proportion
of breast and colon carcinomas are positive for p53 and this
expression correlates with poor prognosis in breast cancer.
These antibodies recognize both wild type and mutant
forms of p53 protein under denaturing and non-denaturing
conditions. Clone IMX25 and p53 CM5 recognize rat and
mouse p53. Clone PAb 1801 recognizes a site between amino
acids 46-55 of the human p53 molecule. Clones D0-1, D0-7
and BP53-12 recognize amino acid sequence 20-25 of the
human p53 molecule. Clone SP5 was raised against the fulllength
human wild type p53 molecule.
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