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p53 Protein Antibody (CM1; rabbit polyclonal)

Clone: Rabbit polyclonal antibody


Breast Cancer: p53 protein stained using VECTASTAIN Elite ABC Kit and Vector DAB (brown) substrate. Hematoxylin QS (blue) counterstain.
 

Catalog # Unit Size Product Information MSDS
VP-P955    0.2 ml   Product Specifications Sheet
Product Specifications Sheet (CE)   		msdsVP.pdf  


Rabbit polyclonal antibody suitable for immunohistochemistry and western blotting.

Functional Aspects:
p53 protein is crucial to normal regulation of cell growth and is a suppressor of tumor cell proliferation. A high proportion of breast and colon carcinomas are positive for p53 and this expression correlates with poor prognosis in breast cancer. These antibodies recognize both wild type and mutant forms of p53 protein under denaturing and non-denaturing conditions. Clone IMX25 and p53 CM5 recognize rat and mouse p53. Clone PAb 1801 recognizes a site between amino acids 46-55 of the human p53 molecule. Clones D0-1, D0-7 and BP53-12 recognize amino acid sequence 20-25 of the human p53 molecule. Clone SP5 was raised against the fulllength human wild type p53 molecule.