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| M2A Antigen Antibody (Lymphatic Endothelial Cell Marker; clone D2-40)
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Mesothelioma (double label): M2A Antigen (m), VECTASTAIN Universal Elite ABC Kit, Vector VIP substrate (purple); CD34 (m), VECTASTAIN Universal Elite ABC Kit, Vector SG substrate (blue/gray).
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Mouse monoclonal antibody suitable for immunohistochemistry on human paraffin embedded, formalin-fixed tissue.
Functional Aspects:
This antibody recognizes the M2A oncofetal antigen, a 40 kDa,
O-linked sialoglycoprotein, expressed on the cell membrane
of lymphatic endothelium, fetal gonocytes, and certain germ
cell tumor cell lines. No reactivity is seen on cancer cell lines
of human breast, prostate, melanoma, cervix, colon, pharynx,
brain, and bone marrow. This antibody has also been shown
to be a useful marker for cells of mesothelial origin, including
malignant mesothelioma.
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